32, 30483058. receives grants for the Department of Radiology fromActelion Pharmaceuticals, Bayer Schering, Bayer Vital, Bristol-Myers Squibb, Charit Research Organisation GmbH, Abbot, BRACCO Group, Deutsche Krebshilfe, Essex Pharma, Guerbet, INC Research, InSightec Ud, IPSEN Pharma, Kendlel MorphoSys AG, Lilly GmbH, MeVis Medical Solutions AG, Nexus Oncology, Novartis, Parexel Clinical Research Organisation Service, Pfizer GmbH, Philipps, Sanofis-Aventis, Siemens, Teruma Medical Corporation, Toshiba, Zukunfsfond Berlin, Amgen, AO Foundation, BARD, BBraun, Boehring Ingelheimer, Brainsgate, CELLACT Pharma, CeloNova Bio-Sciences, North Carolina GlaxoSmithKline Foundation, Jansen, Roehe, Sehumaeher GmbH, Medtronic, Pluristem, Quintiles, Astellas, Chiltern, Respicardia, TEVA, Abbvie, AstraZeneca, Galmed Research and Development. Ibrahim, A. et al. target lesion a Deauville score of 1 or 2 is accepted as a complete response to treatment and especially for interim scans, a score of 3 is also often taken as a complete response. Bethesda, MD 20894, Web Policies This research received no external funding. We extracted all 18 first-order features (energy, total energy, entropy, kurtosis, maximum, minimum, mean, median, interquartile range (IQR), skewness, range, mean absolute deviation (MAD), robust mean absolute deviation (RMAD), root mean squared (RMS), variance, uniformity, 10th percentile and 90th percentile); furthermore, 14 shape features as well as all second- and higher-order features (24Gy level co-occurrence matrix (GLCM) features, 14Gy level dependence matrix (GLDM) features, 16Gy level run-length matrix (GLRLM) features, 16Gy level size zone matrix (GLSZM) features, and five neighboring gray tone difference matrix (NGTDM) features25). https://doi.org/10.3390/jpm13030445, Ibrahim, Firuz, Michela Gabelloni, Lorenzo Faggioni, Subramanyam Padma, Arun R. Visakh, Dania Cioni, and Emanuele Neri. Comparison of first-line chemotherapy including escalated BEACOPP versus chemotherapy including ABVD for people with early unfavourable or advanced stage Hodgkin lymphoma. most exciting work published in the various research areas of the journal. The Spearman between Deauville score and SUV max approach was 0.31 (95% CI, 0.230.38). Based on our findings, patients with an interim SUV, Our findings showed that DS at the interim PET-CT had a specificity and PPV of 100% in predicting a treatment response at 24 months, higher than in previous studies [, Care must be taken when DS is performed as the, Based on our findings, patients can be classified as good or poor responders based on having an rPET value lower or higher than 1.31, respectively, with a sensitivity of 76.1% and a specificity of 100%. Flechsig, P. et al. Fischman, A.J. Brentuximab vedotin combined with ABVD or AVD for patients with newly diagnosed Hodgkin's lymphoma: a phase 1, open-label, dose-escalation study. Dr. Julian Rogasch is participant in the BIH-Charit Digital Clinician Scientist Program funded by the Charit Universittsmedizin Berlin, the Berlin Institute of Health, and the German Research Foundation (DFG). Straus DJ, Dugosz-Danecka M, Connors JM, Alekseev S, Ills , Picardi M, Lech-Maranda E, Feldman T, Smolewski P, Savage KJ, Bartlett NL, Walewski J, Ramchandren R, Zinzani PL, Hutchings M, Munoz J, Lee HJ, Kim WS, Advani R, Ansell SM, Younes A, Gallamini A, Liu R, Little M, Fenton K, Fanale M, Radford J. Lancet Haematol. Minimising the Toxicities of First Line Hodgkin Lymphoma Treatment in the Modern Era. Reconstructed spatial resolution and contrast recovery with Bayesian penalized likelihood reconstruction (Q.Clear) for FDG-PET compared to time-of-flight (TOF) with point spread function (PSF). We aimed to compare the performance of Google Scholar. ; Metzger, M.L. The https:// ensures that you are connecting to the Prognostic value of pretreatment radiomic features of 18F-FDG PET in patients with hodgkin lymphoma. MeSH Eligible patients were age 18-60 years with 1 unfavorable EORTC/LYSA criterion. Leuk. Magn. Sci. PubMedGoogle Scholar. https://doi.org/10.1037//0033-2909.86.2.420 (1979). This site needs JavaScript to work properly. The conventional surgical procedure for lung adenocarcinoma is lobotomy with systematic mediastinal https://doi.org/10.1148/radiol.2020191145 (2020). sharing sensitive information, make sure youre on a federal Progression-free survival (PFS) was well stratified according to a visual assessment of interim PET/CT using 5-PS (p < 0.001). HHS Vulnerability Disclosure, Help It furthermore was the only feature that remained in both datasets after applying different feature reduction techniques. J Clin Oncol. For this, we considered the readings from S.N.N. Cheson BD, Fisher RI, Barrington SF, Cavalli F, Schwartz LH, Zucca E. Biggi A, Gallamini A, Chauvie S, Hutchings M, Kostakoglu L, Gregianin M. Haioun C, Itti E, Rahmouni A, Brice P, Rain JD, Belhadj K. Hutchings M, Barrington SF. This may also be related to a known drawback regarding radiomics, which is their lack of reproducibility, particularly between different scanners16,17,18. Nucl. Google Scholar. Hodgkin's lymphoma. Search dates: April 18, May 17, and May 31, 2018, and August 30, 2019. All articles published by MDPI are made immediately available worldwide under an open access license. Exp Hematol Oncol. PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma [J]. Data Sources: A PubMed search was completed using combinations of the key terms lymphoma, non-Hodgkin, Hodgkin, presentation, diagnosis, staging, treatment, and follow up. The secondary aim was to assess the reproducibility of DS in the interpretation of PET-CT scans. Yhim HY, Eshet Y, Metser U, Lim CH, Lajkosz K, Isaev K, Cooper M, Prica A, Kukreti V, Bhella S, Lang N, Lee KH, Xu W, Hodgson D, Tsang R, Yoon SE, Kim SJ, Kim WS, Crump M, Kuruvilla J, Kridel R. Blood Adv. Before The sensitivity, specificity, PPV, NPV and accuracy of interim DS in predicting a therapy response at 24 months were 80.4%, 100.0%, 100.0%, 40.0% and 82.7%, respectively. and B.H. Considering the results of the MWU test, 41 features from the dataset of scanner A and eight from the dataset of scanner B showed a significant difference between DS4-positive and DS4-negative lesions. Sci. EJNMMI Phys. Mol. These two factors allow to stratify patients into three groups with divergent 2-year EFS: 89% for low-risk (51%; relapsed disease and either pretransplant DS 1-3 or DS 4-5/rMTVlow ; HR 1), 65% for intermediate-risk (28%; refractory disease and either DS 1-3 or DS 4-5/rMTVlow ; HR 3.26), and 45% for high-risk (21%; DS 4-5/rMTVhigh irrespective of disease status; HR 7.61) groups. 2016;17(9):1283-1294. Bhakta, N.; Liu, Q.; Yeo, F.; Baassiri, M.; Ehrhardt, M.J.; Srivastava, D.K. By submitting a comment you agree to abide by our Terms and Community Guidelines. Moskowitz AJ, Schder H, Gavane S, Thoren KL, Fleisher M, Yahalom J, McCall SJ, Cadzin BR, Fox SY, Gerecitano J, Grewal R, Hamlin PA, Horwitz SM, Kumar A, Matasar M, Ni A, Noy A, Palomba ML, Perales MA, Portlock CS, Sauter C, Straus D, Younes A, Zelenetz AD, Moskowitz CH. Younes A, Connors JM, Park SI, Fanale M, O'Meara MM, Hunder NN, Huebner D, Ansell SM. ; data curation, F.I. Lambin, P. et al. CT contrast media could also be avoided, which is beneficial for lymphoma patients, since they are at increased risk of chronic renal insufficiency36. FOIA Milgrom, S. A. et al. Elhamady, H.Y. Management of classical Hodgkin lymphoma: a look at up to date evidence and current treatment approaches. 2023, 13, 445.https:// versus the Deauville score (DS) for assessing the chemotherapy response in pediatric HL patients ; Saleh, S.H. If a relapse occurred at a new site, we classified the examination as "initial". WebOne of the limitations of 18 FDG PET/CT for therapeutic evaluation in Hodgkin's Lymphoma is the relatively high rate of false positive uptake. Use the Previous and Next buttons to navigate the slides or the slide controller buttons at the end to navigate through each slide. Sherief, L.M. It is recommended by the National Comprehensive Cancer Network guidelines and Lugano response criteria for the standardized quantification of FDG uptake in lymphoma manifestations6. Bookshelf https://CRAN.R-project.org/package=caret (2022). Please enable it to take advantage of the complete set of features! Mol. ; project administration, S.N.N. The median age of patients at diagnosis of non-Hodgkin lymphoma is 67 years, and the median age at death is 76. ; Krasin, M.J.; Ness, K.K. Early interim FDG PET/CT prediction of treatment response and prognosis in pediatric Hodgkin disease-added value of low-dose CT. Kluge, R.; Kurch, L.; Georgi, T.; Metzger, M. Current role of FDG-PET in pediatric Hodgkins lymphoma. Rep. 9, 1322. https://doi.org/10.1038/s41598-018-37197-z (2019). 8600 Rockville Pike https://doi.org/10.1097/RLU.0000000000002732 (2019). ; software, A.R.V. ; writingoriginal draft preparation, L.J.J. This study also demonstrated good interobserver agreement. The number of patients is relatively limited regarding the large number of analyzed variables. PET Clin. the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, proved a correlation between lymph node density in standard-dose CT and malignancy in lymph node metastases of a lung cancer rat model by extracting and scanning lymph nodes before the histopathologic examination41. Reproducibility of radiomics for deciphering tumor phenotype with imaging. Purpose: ADS Among the scans that showed discordance, 24 scans scored DS 4/5 were continued on the same treatment regimen and the next assessment showed disease progression. Reproducibility of radiomics is a general concern, restraining the implementation of radiomic signatures into clinical routine37. Med. Imaging https://doi.org/10.1007/s00259-021-05233-2 (2021). Cancer 2005;104:1066-74. WebThe Deauville scoring (DS) system is the current standard for PET response assessment in FL and quantitative criteria, such as SUVmax, have demonstrated the ability to identify the highest risk patients in other lymphoma subtypes. ), or their login data. ; Unal, S.N. Post-therapy DS showed a sensitivity, specificity, PPV, NPV and accuracy of 66.7%, 97.8%, 95.7%, 80% and 94.2%, repsectively. It would also have been desirable to obtain data from a more consistent patient population with a consistent therapy regimen and identical time points of PET/CT. Lymphoma 50, 12571260. WebPre-transplant Deauville score (DS) is an imaging biomarker used for risk stratification in relapsed/refractory classical Hodgkin lymphoma (cHL). Avigdor A, Bulvik S, Levi I, Dann EJ, Shemtov N, Perez-Avraham G. Engert A, Haverkamp H, Kobe C, Markova J, Renner C, Ho A. Context: Positron emission tomography (PET) using F-18 fluorodeoxyglucose (FDG) for treatment monitoring in patients with lymphoma is one of the most well-developed clinical applications. True negative patients were defined as those with no evidence of disease, that is, complete remission at follow-up. Validation of deauville score for response evaluation in hodgkin's lymphoma https://doi.org/10.1182/blood-2018-05-852129 (2018). https://doi.org/10.1007/s00259-014-2715-9 (2014). In these scans we manually marked the previously defined target lesion with a three-dimensional ROI (3D ROI) using 3D Slicer (22, 3D Slicer, Version 4.10.0, http://www.slicer.org). PURPOSE The prognosis of patients with early-stage unfavorable Hodgkin lymphoma remains unsatisfactory. R: A language and environment for statistical computing (R Foundation for Statistical Computing, Vienna, Austria, 2016). 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